scholarly journals Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene

1998 ◽  
Vol 211 (3) ◽  
pp. 228-237 ◽  
Author(s):  
Yong Zeng ◽  
Rania C. Rosborough ◽  
Yanjiao Li ◽  
Abha R. Gupta ◽  
Jean Bennett
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Herve Faralli ◽  
F. Jeffrey Dilworth

Expression of themyogenin(Myog) gene is restricted to skeletal muscle cells where the transcriptional activator turns on a gene expression program that permits the transition from proliferating myoblasts to differentiating myotubes. The strict temporal and spatial regulation onMyogexpression in the embryo makes it an ideal gene to study the developmental regulation of tissue-specific expression. Over the last 20 years, our knowledge of the regulation ofMyogexpression has evolved from the identification of the minimal promoter elements necessary for the gene to be transcribed in muscle, to a mechanistic understanding of how the proteins that bind these DNA elements work together to establish transcriptional competence. Here we present our current understanding of the developmental regulation of gene expression gained from studies of theMyoggene.


Genetics ◽  
2010 ◽  
Vol 186 (4) ◽  
pp. 1217-1230 ◽  
Author(s):  
Charles J. Greenwald ◽  
Takao Kasuga ◽  
N. Louise Glass ◽  
Brian D. Shaw ◽  
Daniel J. Ebbole ◽  
...  

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